cees dekker - An Overview
cees dekker - An Overview
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Nanotechnology features a range of chances to add to biology. Here I will present examples the place nanofabrication – a chance to make confined buildings with Proportions at will – is used to examine the biophysics of single molecules and cells. I will present some examples from our lab:
Our team scientific tests bacterial cell division and is particularly aiming to represent a ‘bottom up biology’ in artificial cells which will autonomously divide. Our major curiosity lies in cell division, chromatin composition, and spatial Management.
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Non-equilibrium folding of individual DNA molecules recaptured around one thousand instances in the reliable condition nanopore
That could be a desire of mine and we set to work which has a tasty dose of naivety. This is often something that will most likely generate magnificent ends in the for a longer period phrase, but that doesn't make any difference. You should not only want to work to the questions of tomorrow, but additionally about the thoughts from the day immediately after tomorrow.’
Microbiology has only been around to get a century, considering that we began to review micro-organisms additional very seriously. I assumed nanobiology was an proper phrase, due to the fact all molecular Organic suitable interactions occur for the nanoscale: a protein is a handful of nanometres in sizing, DNA is two nm thick.’
All parameters had been precisely the same for every panel With this online video, except for the initial placement from the 6hb rod (proven in blue) about the nanopore. Simulations that terminated early resulting from translocation from the rod with the pore are marked by a grey track record.
Researching DNA loop extrusion by SMC proteins for chromosome architecture with single-molecule assays.
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Dekker begun his exploration on single carbon nanotubes in 1993 when he arrange a different line of analysis to study electrical transportation via one natural molecules between nanoelectrodes. In 1996 a breakthrough was recognized with carbon nanotubes. This was accomplished inside of a collaboration With all the team of Nobel laureate Richard Smalley. STM and nanolithography tactics were utilized to exhibit that these nanotubes are quantum wires at the single-molecule degree, with outstanding Bodily properties.
An built-in microfluidic System for quantifying drug permeation across biomimetic vesicle membranes
‘That issues the artificial mobile, as A part of the Dutch BaSyC initiative. Craig Venter seemed top-down in Individuals times and identified about five ceesdekker.net hundred genes that happen to be minimally required for your functioning cell. We want to glimpse bottom-up: how do we go from the couple of molecules to a whole Organic procedure?
Visualization of unstained DNA nanostructures with advanced in-target transmission electron microscopy tactics
Supercoiling-dependent DNA binding: quantitative modeling and programs to bulk and one-molecule experiments